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Current Trends in Clinical Embryology

Comparison of ICSI results in a group of patients with and without oral L-carnitine, acetyl-L-carnitine and nutrients supplementation

Original Article, 99 - 107
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Abstract
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Epidemiological, preclinical and clinical studies show that specific metabolic compounds and nutrients play an important role in oocyte and embryo development.
Metabolic compounds like L-carnitine and acetyl-L-carnitine play a role in fertility related processes by facilitating LH levels and oocyte development. However, the effects of using these substrates and nutrients to improve ICSI outcomes are not clear.
The aim of our work was to evaluate the effect of these carnitines, N-acetyl cysteine and other specific vitamins and minerals on ICSI outcomes in couples with infertility. Infertile couples (n=56) were enrolled and followed over a period of one year. The couples had already done a cycle of ICSI without any treatment and were than treated with the supplement for two months followed by the next ICSI cycle. The group of women underwent hormonal treatment followed by follicular aspiration, intra-cytoplasmic spermatozoa injection and embryo transfer. The comparison of the results between the two cycles of ICSI with and without supplement, showed a significant improvement in the number of mature oocytes (5.2 ± 3.2 vs 7.3 ± 4.4, p=0.04), the level of embryos, type I (40% ± 10.5 vs 65% ± 12.2, p=0.02), blastocyst levels (22% ± 10.5 vs 33% ± 7.5, p=0.02) and the top quality blastocyst rate (25.3% ± 10.8 vs 45.2% ± 10.6, p=0.01) following supplementation.
The biological pregnancy rate also increased from 17% ± 2.1 to 22% ± 2.3 with p=0.07, and this attained significance if we only looked at the values for the group of women <35 years. The treatment duration of two months and group number was probably not sufficient to significantly improve the ICSI results in women >35 years. The results show that supplementation improves many biological parameters as well as results of ICSI and could be beneficial in the overall rate of pregnancy in couples with infertility.
Further studies are necessary to examine the role in ICSI as well as studies of longer duration and with larger and more homogeneous population size to show the role of specific nutrients in fertility.

Vol. 5 (No. 3) 2018 September - December

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  5. Formation and dynamics of the primordial follicle stockpile
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  6. Human sperm vitrification: state of the art
    Caponecchia L., Coltrinari G., Finocchi F., Sacchetto R., Paoli D.
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  1. Comparison of ICSI results in a group of patients with and without oral L-carnitine, acetyl-L-carnitine and nutrients supplementation
    Ajina M., Mustapha H., Tagorti S., Virmani M.A.
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